CoQ10 acts as an electron transport carrier in the mitochondrial respiratory chain and is particularly important in cell energy production. Moreover, CoQ10 has antioxidant, anti-inflammatory, anti-apoptotic, and protective vascular endothelial effects. In addition, CoQ10 is "recycling" and "ubiquitous" You can let it play the role of a screw everywhere.
Current clinical applications of CoQ10 include: human CoQ10 deficiency, mitochondrial disease, fibromyalgia, cardiovascular diseases (such as heart failure, ischemic heart disease, interactions with statins, hypertension), neurodegenerative diseases (For example: Parkinson's disease, Huntington's disease, Alzheimer's disease, Friedreich's ataxia, etc.), diabetes, cancer, male infertility, female infertility, Down syndrome, periodontal disease, migraine, Bipolar disorder, aging…
CoQ10 and cardiovascular disease
When human beings are 20 years old, their ability to independently synthesize CoQ10 reaches its peak, remains until about 50 years old, and then declines year by year. The reduction in CoQ10 mass concentration is especially obvious in the high-energy-consuming heart. The CoQ10 in the myocardium of a 77-year-old man is even more than 50% lower than that of a 20-year-old young man. This is why CoQ10’s most famous title is “Heart Protector”!
Everyone should have heard about cardiovascular disease. Even for people who are in good health, their hearts will begin to age after the age of 50, and the probability of suffering from cardiovascular disease will increase.
This is because the mitochondria of aging cardiomyocytes produce too much free oxygen (ROS), which can damage the protein, DNA, membrane structure, etc. in the myocardium, and produce a variety of stress products, which can lead to vascular and myocardial fibrosis. Fibrosis can affect heart function and cause cardiovascular diseases such as heart failure.
CoQ10 can affect cardiovascular disease through:
1. Involved in energy production, the reduction of coenzyme Q10 is closely related to heart failure;
2. It has antioxidant effect, can eliminate ROS and reduce the damage of ROS to the membrane;
3. Regenerate vitamin E and vitamin C, strengthen the antioxidant effect, prevent free radicals from peroxidizing membrane phospholipids, and avoid oxidative damage to mitochondrial DNA and membrane proteins;
4. Combine with low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) to prevent lipid peroxidation damage, thus exerting beneficial effects on cardiovascular disease;
5. By reducing nitric oxide (NO) consumption, maintaining NO content, promoting the production of prostacyclin, and improving the function of vascular endothelium;
6. Reduce the levels of C-reactive protein, interleukin-6 and tumor necrosis factor in blood vessels and weaken vascular inflammation.
Cicero et al. summarized the major clinical trials of CoQ10 in the treatment of chronic heart failure from 1980 to 2016 and concluded that CoQ10 supplementation can significantly improve the quality of life and clinical outcomes of patients with heart failure.
In an experiment in patients with atherosclerosis, taking 150 mg of CoQ10 daily orally reduced oxidative stress, increased antioxidant enzyme activity, and lowered inflammatory markers. The researchers pointed out that CoQ10 may play an important role in the primary prevention of cardiovascular disease.
CoQ10 and diabetes
Diabetes is a chronic metabolic disease involving metabolic disorders of carbohydrates, lipids, and proteins, and many studies have shown that oxidative stress plays a central role in the pathogenesis of this multifaceted metabolic disease. This has led to research into the use of antioxidants as complementary treatments!
Patients with type II diabetes have low serum CoQ10 levels, which can be reversed by exogenous supplementation of CoQ10:
In three separate randomized, double-blind clinical trials, a total of 194 patients with type 2 diabetes received 200 mg of CoQ10 or placebo daily for 12 weeks. One of the studies also compared CoQ10 stand-alone treatment with CoQ10-fenofibrate combination and fenofibrate (a lipid-lowering drug) alone. The results found that supplementing CoQ10 in this population can increase plasma CoQ10 levels, improve the endothelial function of the brachial artery, significantly reduce systolic blood pressure and diastolic blood pressure, and reduce glycated hemoglobin (HbA1C); and combined with fenofibrate, it can significantly reduce Improves relaxation of endothelial and non-endothelial forearm blood vessels.
CoQ10 and Parkinson’s syndrome
Parkinson's disease (Parkinson's syndrome) is a degenerative disease of the central nervous system that is common in middle-aged and elderly people. Muhammad Ali suffered from Parkinson's disease after his retirement, and doctors believe it may be related to the more than 29,000 blows he suffered to the head during his career. I wonder if you still remember the touching scene of Ali lighting the torch tremblingly.
Extensive preclinical studies in Parkinson's models have shown that CoQ10 protects the nigrostriatal dopaminergic system, the main site of Parkinson's disease.
CoQ10 can intervene in Parkinson’s disease through the following ways:
1. Effectively combat oxidative stress, increase the activity of succinate cytochrome C reductase in substantia nigra cells, and directly combat lipid peroxidation caused by free radicals at the cell membrane level;
2. Maintain its oxidative phosphorylation function by protecting the structural integrity of mitochondria, inhibiting the dispersion of phospholipases on cell membrane phospholipids, resisting the generation of free radicals, and protecting and stabilizing cell membranes;
3. Prevent the reduction of protein sulfhydryl groups in the substantia nigra of Parkinson's patients, improve the activity of complex I in mitochondria, maintain the level of ATP, and reduce the adverse consequences of Parkinson's patients.
In a double-blind clinical trial, 300 mg of reduced CoQ10 per day was safe for Parkinson's patients, and by reversing abnormal mitochondrial characteristics, it improved tremor symptoms in Parkinson's patients better than a placebo group.
In experiments on Parkinson's mouse models, it was found that the plasma CoQ10 concentration of mice supplemented with 200 mg/kg/day CoQ10 and reduced CoQ10 was higher than that of the oxidized type, indicating that as a supplement, reduced CoQ10 is more effective than the oxidized type.
CoQ10 and glaucoma
Glaucoma is the leading cause of visual impairment and irreversible blindness worldwide and is characterized by the loss of retinal ganglion cells (RGCs). Increasing evidence suggests that age-related mitochondrial defects play a central role in the pathogenesis of glaucoma.
In a recent glaucoma study in mice, researchers who supplemented glaucoma mice with CoQ10 for 6 months (with controls) found that: CoQ10 reduced glaucoma in the retina and optic nerve head of mice with glaucoma. The expression of fibrillary acidic protein protects optic nerve head axons and inhibits astrocyte activation to support RGC survival.
CoQ10 can significantly inhibit the upregulation or expression of proteins related to pathogenesis in the retina of glaucoma mice. In addition, CoQ10 can prevent cell apoptosis, and mitochondria in the retinal tissue of glaucoma mice were protected after CoQ10 supplementation.
Although the experiment was only in a mouse model, the level of CoQ10 in the human retina also declines with age. The potential of CoQ10 to improve retinal neurodegeneration may also be helpful to humans, and we look forward to human clinical trials.
CoQ10 and aging
Antioxidant——>Anti-aging
This simple and crude formula is still easy to use. Indeed, as a useful antioxidant, CoQ10 can scavenge free radicals, protect mitochondria, and increase ATP production (see the previous article for details, there should be a link here for directions), which are all considered to be helpful in anti-aging. . The role of CoQ10 in several age-related diseases was also introduced earlier. In addition, the synthesis of CoQ10 in the body decreases as age increases, indicating that CoQ10 is inseparable from age.
However, in experiments on animal models, dietary supplementation of CoQ10 to extend the lifespan of various animals has no effect. However, it is very useful in reversing the aging phenotype, which is consistent with the impact on age-related diseases described previously. Other studies have shown that coenzyme Q10 can inhibit D-galactose-induced senescence of mesenchymal stem cells through Akt/mTOR signaling.
Many cosmetics also contain CoQ10. Studies have shown that CoQ10 can accelerate the respiration level of skin damaged by light, increase ATP synthesis, and reduce skin DNA damage. Compared with the control group, both the low-dose (50mg/day) and high-dose (150mg/day) groups showed the effect of reducing wrinkles and diluting fine lines... Miraculously, this study used highly bioavailable water-soluble CoQ10 Dosage form (Q10Vital®).
Changes in eye wrinkles in two 60-year-old volunteers before and after oral administration of Coenzyme Q10 (0-12 weeks)
Who is suitable for supplementing CoQ10:
1. People involved in clinical applications of CoQ10: Symptoms can be relieved by supplementing CoQ10.
2. People taking statins: As drugs to prevent cardiovascular disease, statins are often used to treat elevated cholesterol and dyslipidemia. However, statins can reduce CoQ10 in muscles, causing mitochondrial dysfunction, leading to muscle soreness, myositis and even rhabdomyolysis. Therefore, it is best to supplement CoQ10 when taking statins.
Video source:https://www.youtube.com/watch?v=7T8jpFQgrvk&t=65s(Creator:HealthRX )
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Coenzyme Q10（CoQ10） manufacturers and suppliers!
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